+1 (Relative to A site) site for up-regulated genes

+1 (Relative to A site) site for down-regulated genes

+2 (Relative to A site) site for up-regulated genes

+2 (Relative to A site) site for down-regulated genes

+3 (Relative to A site) site for up-regulated genes

+3 (Relative to A site) site for down-regulated genes